Peripheral whole blood microRNA expression in relation to vascular function: a population-based study.

ABSTRACT:

Background

As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several cardiovascular diseases. In this study, we aimed to investigate the relation of whole blood microRNAs with several quantitative measurements of vascular function, and explore their biological role through an integrative microRNA-gene expression analysis.

Methods

Peripheral whole blood microRNA expression was assessed through RNA-Seq in 2606 participants (45.8% men, mean age: 53.93, age range: 30 to 95 years) from the Rhineland Study, an ongoing population-based cohort study in Bonn, Germany. Weighted gene co-expression network analysis was used to cluster microRNAs with highly correlated expression levels into 14 modules. Through linear regre

SUBMITTER: Talevi V 

PROVIDER: S-EPMC11264787 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature