High cognitive reserve attenuates the risk of dementia associated with cardiometabolic diseases.

ABSTRACT:

Background

Cardiometabolic diseases (CMDs) including type 2 diabetes, heart disease, and stroke have been linked to a higher risk of dementia. We examined whether high levels of cognitive reserve (CR) can attenuate the increased dementia risk and brain pathologies associated with CMDs.

Methods

Within the UK Biobank, 216,178 dementia-free participants aged ≥ 60 were followed for up to 15 years. Baseline CMDs and incident dementia were ascertained from medical records, medication use, and medical history. Latent class analysis was used to generate an indicator of CR (low, moderate, and high) based on education, occupational attainment, confiding in others, social contact, leisure activities, and television watching time. A subsample (n = 13,663) underwent brain MRI scans durin

SUBMITTER: Dove A 

PROVIDER: S-EPMC11264799 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature