Soluble CD44 in oral rinses for the early detection of cancer: a prospective cohort study in high-risk individuals.

ABSTRACT:

Background

There are 54,000 new cases of oral cavity and oropharyngeal cancer in the United States and more than 476,000 worldwide each year. Oral cavity and oropharyngeal squamous cell carcinoma make up most tumors with five-year survival rates of 50% due to prevalence of late-stage diagnoses. Improved methods of early detection in high-risk individuals are urgently needed. We aimed to assess the tumorigenic biomarkers soluble CD44 (solCD44) and total protein (TP) measured using oral rinses as affordable convenient screening tools for cancer detection.

Methods

In this prospective cohort study, we recruited 150 healthy current or former smokers through a community screening program. Baseline and four annual visits were conducted from March 2011-January 2016 with records foll

SUBMITTER: Raslan S 

PROVIDER: S-EPMC11264816 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature