Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophy.

ABSTRACT: Background: Duchenne muscular dystrophy is a genetic disease produced by mutations in the dystrophin gene characterized by early onset muscle weakness leading to severe and irreversible disability. Muscle degeneration involves a complex interplay between multiple cell lineages spatially located within areas of damage, termed the degenerative niche, including inflammatory cells, satellite cells (SCs) and fibro-adipogenic precursor cells (FAPs). FAPs are mesenchymal stem cell which have a pivotal role in muscle homeostasis as they can either promote muscle regeneration or contribute to muscle degeneration by expanding fibrotic and fatty tissue. Although it has been described that FAPs could have a different behavior in DMD patients than in healthy controls, the molecular pathways regu

SUBMITTER: Fernandez-Simon E 

PROVIDER: S-EPMC11264872 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature