Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanoma.

ABSTRACT:

Background

Uveal melanoma is the most common non-cutaneous melanoma and is an intraocular malignancy affecting nearly 7,000 individuals per year worldwide. Of these, approximately 50% will progress to metastatic disease for which there are currently no effective curative therapies. Despite advances in molecular profiling and metastatic stratification of uveal melanoma tumors, little is known regarding their underlying biology of metastasis. Our group has identified a disseminated neoplastic cell population characterized by co-expression of immune and melanoma proteins, circulating hybrid cells (hybrids), in patients with uveal melanoma. Compared to circulating tumor cells, which lack expression of immune proteins, hybrids are detected at an increased prevalence in peripheral blood

SUBMITTER: Anderson AN 

PROVIDER: S-EPMC11264923 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature