Six adenoviral vectored African swine fever virus genes protect against fatal disease caused by genotype I challenge.

ABSTRACT: African swine fever virus causes a lethal hemorrhagic disease in domestic swine and wild boar for which currently licensed commercial vaccines are only available in Vietnam. Development of subunit vaccines is complicated by the lack of information on protective antigens as well as suitable delivery systems. Our previous work showed that a pool of eight African swine fever virus genes vectored using an adenovirus prime and modified vaccinia virus boost could prevent fatal disease after challenge with a virulent genotype I isolate of the virus. Here, we identify antigens within this pool of eight that are essential for the observed protection and demonstrate that adenovirus-prime followed by adenovirus-boost can also induce protective immune responses against genotype I African swine fever v

SUBMITTER: Portugal R 

PROVIDER: S-EPMC11264932 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature