AStruct: detection of allele-specific RNA secondary structure in structuromic probing data.

ABSTRACT:

Background

Uncovering functional genetic variants from an allele-specific perspective is of paramount importance in advancing our understanding of gene regulation and genetic diseases. Recently, various allele-specific events, such as allele-specific gene expression, allele-specific methylation, and allele-specific binding, have been explored on a genome-wide scale due to the development of high-throughput sequencing methods. RNA secondary structure, which plays a crucial role in multiple RNA-associated processes like RNA modification, translation and splicing, has emerged as an essential focus of relevant research. However, tools to identify genetic variants associated with allele-specific RNA secondary structures are still lacking.

Results

Here, we develop a computational

SUBMITTER: Xu Q 

PROVIDER: S-EPMC11264973 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature