CXCL5 impedes CD8⁺ T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis.

ABSTRACT:

Background

Lung cancer remains one of the most prevalent cancer types worldwide, with a high mortality rate. Upregulation of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) may represent a key mechanism for evading immune surveillance. Immune checkpoint blockade (ICB) antibodies against PD-1 or PD-L1 are therefore widely used to treat patients with lung cancer. However, the mechanisms by which lung cancer and neutrophils in the microenvironment sustain PD-L1 expression and impart stronger inhibition of CD8⁺ T cell function remain unclear.

Methods

We investigated the role and underlying mechanism by which PD-L1⁺ lung cancer and PD-L1⁺ neutrophils impede the function of CD8⁺ T cells through magnetic bead cell sorting, q

SUBMITTER: Sun D 

PROVIDER: S-EPMC11264977 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature