Putative new combination vaccine candidates identified by reverse vaccinology and genomic approaches to control enteric pathogens.

ABSTRACT:

Objectives

The pathogenic microorganisms that cause intestinal diseases can significantly jeopardize people's health. Currently, there are no authorized treatments or vaccinations available to combat the germs responsible for intestinal disease.

Methods

Using immunoinformatics, we developed a potent multi-epitope Combination (combo) vaccine versus Salmonella and enterohemorrhagic E. coli. The B and T cell epitopes were identified by performing a conservancy assessment, population coverage analysis, physicochemical attributes assessment, and secondary and tertiary structure assessment of the chosen antigenic polypeptide. The selection process for vaccine development included using several bioinformatics tools and approaches to finally choose two linear B-cell epitopes, five C

SUBMITTER: Mikaeel S 

PROVIDER: S-EPMC11265179 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature