<i>In vivo</i> efficacy of phage cocktails against carbapenem resistance <i>Acinetobacter baumannii</i> in the rat pneumonia model.

ABSTRACT: Acinetobacter baumannii, an opportunistic pathogen, poses a significant threat in intensive care units, leading to severe nosocomial infections. The rise of multi-drug-resistant strains, particularly carbapenem-resistant A. baumannii, has created formidable challenges for effective treatment. Given the prolonged development cycle and high costs associated with antibiotics, phages have garnered clinical attention as an alternative for combating infections caused by drug-resistant bacteria. However, the utilization of phage therapy encounters notable challenges, including the narrow host spectrum, where each phage targets a limited subset of bacteria, increasing the risk of phage resistance development. Additionally, uncertainties in immune system dynamics during treatment hind

SUBMITTER: Li S 

PROVIDER: S-EPMC11265278 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature