Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris.

ABSTRACT:

Introduction

Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations), remains poorly understood. Methods: Four clinical cases and 29 isolates associated with the incremental process of echinocandin resistance were collected and analyzed using antifungal drug susceptibility testing and genome sequencing to assess the evolution of echinocandin resistance.

Findings

Six echinocandin minimum inhibitory concentration (MIC)-elevated C. auris strains and seven resistant strains were isolated from the urinary system of patients receiving echinocandin treatment. Meanwhile,

SUBMITTER: Tian S 

PROVIDER: S-EPMC11265302 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature