Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis.

ABSTRACT:

Background

Empirical research has consistently documented the concurrent manifestation of frailty and chronic kidney disease (CKD). However, the existence of a reverse causal association or the influence of confounding variables on these correlations remains ambiguous.

Methods

Our analysis of 7,078 participants from National Health and Nutrition Examination Survey(NHANES) (1999-2018) applied weighted logistic regression and Mendelian Randomization (MR) to investigate the correlation between the frailty index (FI) and renal function. The multivariate MR analysis was specifically adjusted for type 2 diabetes and hypertension. Further analysis explored 3282 plasma proteins to link FI to CKD. A two-step network MR highlighted immune cells' mediating roles in the FI-CKD relations

SUBMITTER: Zheng G 

PROVIDER: S-EPMC11265307 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature