Hippocampal PACAP signaling activation triggers a rapid antidepressant response.

ABSTRACT:

Background

The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response.

Methods

The onset of antidepressant response was assessed through depression-related behavioral paradigms. The signaling mechanism of PACAP in the hippocampal dentate gyrus (DG) was evaluated by utilizing site-directed gene knockdown, pharmacological interventions, or optogenetic manipulations. Overall, 446 mice were used for behavioral and molecular signaling testing. Mice wer

SUBMITTER: Zhang HL 

PROVIDER: S-EPMC11265467 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature