A novel nanocomposite drug delivery system for SARS-CoV-2 infections.

ABSTRACT: To develop an inhalable drug delivery system, we synthesized poly (lactic-co-glycolic acid) nanoparticles with Remdesivir (RDV NPs) as an antiviral agent against SARS-CoV-2 replication and formulated Remdesivir-loaded nanocomposites (RDV NCs) via coating of RDV NPs with novel supramolecular cell-penetrating peptide nanofibers (NFs) to enhance cellular uptake and intracellular drug delivery. RDV NPs and RDV NCs were characterized using variou techniques, including Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS), and fluorescent microscopy. The cytotoxicity of RDV NCs was assessed in Vero E6 cells and primary human lung epithelial cells, with no significant cytotoxicity observed up to 1000 μg mL^-1 and 48 h. RDV NCs were spherically shaped with

SUBMITTER: Chintapula U 

PROVIDER: S-EPMC11265598 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature