Head circumferences measured during developmental monitoring visits before diagnosis of childhood-onset craniopharyngioma.

ABSTRACT:

Background

Craniopharyngiomas (CP) are histologically benign (WHO grade 1), embryonal malformations which are related to remnants of the Rathke's pouch and are located in the (peri)sellar region. Already before CP diagnosis, many patients show a reduced growth velocity and tend to present with weight gain. However, it is unknown whether patients with CP develop an increased head circumference (HC) before CP diagnosis, which could be a useful early diagnostic indicator.

Patients and methods

For a cohort of 83 patients recruited in the multicenter studies KRANIOPHARYNGEOM 2000 and HIT-ENDO data on HC could be analyzed, based on medical records assessed in developmental monitoring visits performed at defined time points before CP diagnosis.

Results

When comparing HC stan

SUBMITTER: Beckhaus J 

PROVIDER: S-EPMC11265653 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature