HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis.

ABSTRACT:

Introduction

Genetic predisposition to autoimmune encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of associated environmental factors (tumors, infections), we hypothesized that human leukocyte antigen (HLA) and killer-cell immunoglobulin-like receptors (KIR), two extremely polymorphic gene complexes key to the immune system, might be relevant for the genetic predisposition to anti-NMDAR encephalitis. Notably, KIR are chiefly expressed by Natural Killer (NK) cells, recognize distinct HLA class I allotypes and play a major role in anti-tumor and anti-infection responses.

Methods

We conducted a Genome Wide Association Study (GWAS) with subsequent control-matching using Principal Component Analysi

SUBMITTER: Peris Sempere V 

PROVIDER: S-EPMC11266021 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature