The causal relationship between gut microbiota and diabetic neuropathy: a bi-directional two-sample Mendelian randomization study.

ABSTRACT:

Background

Many studies suggest a strong correlation between gut microbiota (GM) and diabetic neuropathy (DN). However, the precise causal relationship between GM and DN has yet to be fully elucidated. Hence, a bi-directional Mendelian randomization (MR) analysis was used to examine the association between GM and DN.

Methods

Widely known genome-wide association study (GWAS) of GM was collected from the MiBio Gen project. Summary-level datasets for DN were taken from the FinnGen project. Inverse variance weighted approach was used for evaluating the causal relationship between GM and DN. Subsequently, pleiotropy and heterogeneity tests were performed to verify the reliability of the data. Furthermore, a bidirectional two-sample MR analysis was done to investigate the directio

SUBMITTER: Xie L 

PROVIDER: S-EPMC11266094 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature