Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity.

ABSTRACT:

Introduction

Obesity is associated with a plethora of health complications, including increased susceptibility to infections or decreased vaccine efficacy, partly due to dysregulated immune responses. Monocytes play a crucial role in innate immunity, yet their functional alterations in obesity remain poorly understood.

Methods

Here, we employed proteomic and metabolomic analyses to investigate monocyte characteristics in individuals with overweight, obesity, impaired glucose tolerance (IGT), and type 2 diabetes (T2D), compared to lean donors.

Results and discussion

Our results revealed distinct molecular signatures in monocytes from individuals with obesity, with significant alterations in pathways related to metabolism, cellular migration, and phagocytosis. Moreover,

SUBMITTER: Radushev V 

PROVIDER: S-EPMC11266186 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature