Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands.

ABSTRACT:

Objectives

Certain Group B Streptococcus (GBS) genotypes are associated with invasive disease in neonates. We conducted a comparative genomic analysis of GBS isolates from neonatal disease and maternal carriage in the Netherlands to determine distribution of genetic markers between the two host groups.

Methods

Whole genome sequencing was used to characterise 685 neonatal invasive isolates (2006-2021) and 733 maternal carriage isolates (2017-2021) collected in the Netherlands.

Results

Clonal complex (CC) 17 and serotype III were significantly more common in disease while carriage isolates were associated with serotypes II, IV, V as well as CC1. Previously reported CC17-A1 sub-lineage was dominant among disease isolates and significantly less common in carriage. The phi

SUBMITTER: Khan UB 

PROVIDER: S-EPMC11266191 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature