Left Frontoparietal Control Network Connectivity Moderates the Effect of Amyloid on Cognitive Decline in Preclinical Alzheimer's Disease: The A4 Study.

ABSTRACT:

Background

Stronger resting-state functional connectivity of the default mode and frontoparietal control networks has been associated with cognitive resilience to Alzheimer's disease related pathology and neurodegeneration in smaller cohort studies.

Objectives

We investigated whether these networks are associated with longitudinal CR to AD biomarkers of beta-amyloid (Aβ).

Design

Longitudinal mixed.

Setting

The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) study and its natural history observation arm, the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) study.

Participants

A sample of 1,021 cognitively unimpaired older adults (mean age = 71.2 years [SD = 4.7 years], 61% women, 42% APOEε4 carriers, 52% Aβ positive).<

SUBMITTER: Boyle R 

PROVIDER: S-EPMC11266218 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature