Association between Resting Heart Rate and Machine Learning-Based Brain Age in Middle- and Older-Age.

ABSTRACT:

Background

Resting heart rate (RHR), has been related to increased risk of dementia, but the relationship between RHR and brain age is unclear.

Objective

We aimed to investigate the association of RHR with brain age and brain age gap (BAG, the difference between predicted brain age and chronological age) assessed by multimodal Magnetic Resonance Imaging (MRI) in mid- and old-aged adults.

Design

A longitudinal study from the UK Biobank neuroimaging project where participants underwent brain MRI scans 9+ years after baseline.

Setting

A population-based study.

Participants

A total of 33,381 individuals (mean age 54.74 ± 7.49 years; 53.44% female).

Measurements

Baseline RHR was assessed by blood pressure monitor and categorized as <60, 60-69 (referenc

SUBMITTER: Wang J 

PROVIDER: S-EPMC11266275 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature