Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine Versus Nimenrix in Healthy Adolescents: A Randomized Phase IIIb Multicenter Study.

ABSTRACT:

Introduction

Many immunization programs in Europe recommend quadrivalent meningococcal vaccinations, which are often administered concomitantly with other vaccines. We compared the immune response of a tetanus toxoid conjugated quadrivalent meningococcal vaccine (MenACYW-TT, MenQuadfi^®) with another quadrivalent meningococcal conjugate vaccine (MCV4-TT; Nimenrix^®) when administered alone or concomitantly with Tdap-IPV and 9vHPV vaccines in adolescents.

Methods

In this phase IIIb trial, healthy adolescents (MenC-naïve or MenC-primed before 2 years of age) from Spain, Italy, Hungary, and Singapore were randomized in a 3:3:2 ratio to receive either MenACYW-TT or MCV4-TT alone, or MenACYW-TT concomitantly with 9vHPV and Tdap-IPV. The primary objective was t

SUBMITTER: Diez-Domingo J 

PROVIDER: S-EPMC11266330 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature