Association between parity and pregnancy-associated tumor features in high-grade serous ovarian cancer.

ABSTRACT:

Purpose

High-grade serous ovarian cancer (HGSC) is the most common ovarian cancer subtype. Parity is an important risk-reducing factor, but the underlying mechanism behind the protective effect is unclear. Our aim was to study if the expression of hormones and proteins involved in pregnancy were affected by the woman's parity status, and if they may be associated with tumor stage and survival.

Methods

We evaluated expression of progesterone receptor (PR), progesterone receptor membrane component 1 (PGRMC1), relaxin-2, and transforming growth factor beta 1 (TGFβ1) in tumor tissue from 92 women with HGSC parous (n = 73) and nulliparous (n = 19). Key findings were then evaluated in an independent expansion cohort of 49 patients. Survival rates by hormone/protein expression were

SUBMITTER: Skold C 

PROVIDER: S-EPMC11266373 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature