Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial.

ABSTRACT:

Background

It remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised-compared to routine-intraoperative blood pressure management reduces the incidence of postoperative neurocognitive disorders in patients having major noncardiac surgery.

Methods

In this single-centre trial, 328 elective major noncardiac surgery patients were randomly allocated to receive personalised blood pressure management (i.e. maintaining intraoperative mean arterial pressure [MAP] above preoperative baseline MAP from automated 24-h blood pressure monitoring) or routine blood pressure management (i.e. maintaining MAP above 65 mm Hg). The primary outcome was the incidence of neurocog

SUBMITTER: Nicklas JY 

PROVIDER: S-EPMC11267063 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature