Diagnostic and Prognostic Value of Plasma lncRNA SRA1 in Chronic Heart Failure.

ABSTRACT:

Background

The pathogenesis and development of chronic heart failure (CHF) may involve long non-coding ribonucleic acid (lncRNA) steroid receptor RNA activator 1 (SRA1), a known cardiomyopathy risk factor and regulator of cardiac myofibroblast activation. This study aimed to investigate the application of SRA1 in the early detection and prediction of CHF.

Methods

SRA1 plasma expression was determined in CHF patients and healthy individuals/using real time-quantitative polymerase chain reaction (RT-qPCR). The diagnostic and prognostic value of SRA1 was assessed using receiver operating curve (ROC) and Cox regression analyses.

Results

Compared with the healthy controls, the patients with CHF had increased brain natriuretic peptide (BNP) levels, left atrial end-systolic

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11267213 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature