Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m⁶A Epitranscriptome via Bile Acid Metabolism.

ABSTRACT: Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N⁶-methyladenosine (m⁶A), the most abundant mammalian mRNA modification. However, which and how gut microbiota-derived metabolites reprogram host transcriptome and m⁶A epitranscriptome remain poorly understood. Here, investigation is conducted into how gut microbiota-derived metabolites impact host transcriptome and m⁶A epitranscriptome using multiple mouse models and multi-omics approaches. Various antibiotics-induced dysbiotic mice are established, followed by fecal microbiota transplantation (FMT) into germ-free mice, and the results show

SUBMITTER: Yang M 

PROVIDER: S-EPMC11267274 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature