Gene signatures of copper metabolism related genes may predict prognosis and immunity status in Ewing's sarcoma.

ABSTRACT:

Background

Cuproptosis is copper-induced cell death. Copper metabolism related genes (CMRGs) were demonstrated that used to assess the prognosis out of tumors. In the study, CMRGs were tested for their effect on TME cell infiltration in Ewing's sarcoma (ES).

Methods

The GEO and ICGC databases provided the mRNA expression profiles and clinical features for downloading. In the GSE17674 dataset, 22prognostic-related copper metabolism related genes (PR-CMRGs) was identified by using univariate regression analysis. Subsequently, in order to compare the survival rates of groups with high and low expression of these PR-CMRGs,Kaplan-Meier analysis was implemented. Additionally, correlations among them were examined. The study employed functional enrichment analysis to investigate pr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11267503 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature