Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.

ABSTRACT: With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, including cancer, diabetes, and metabolic and neurological disorders. They represent an important therapeutic target class that remains only partly exploited as therapeutics that target SLCs are scarce. Additionally, many small molecules reported in the literature to target SLCs are poorly characterized. Both features may be due to the difficulty of developing SLC transport assays that fulfill the quality criteria for high-throughput screening. Here, we report one of the main limitations hampering assay development within the RESOLUTE consortium:

SUBMITTER: Digles D 

PROVIDER: S-EPMC11267547 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature