Spatial Resolution for X-ray Excited Luminescence Chemical Imaging (XELCI).

ABSTRACT: Measuring chemical concentrations at the surface of implanted medical devices is important for elucidating the local biochemical environment, especially during implant infection. Although chemical indicator dyes enable chemical measurements in vitro, they are usually ineffective when measuring through tissue because the background obscures the dye signal and scattering dramatically reduces the spatial resolution. X-ray excited luminescent chemical imaging (XELCI) is a recent imaging modality which overcomes these limitations using a focused X-ray beam to excite a small spot of red light on scintillator-coated medical implants with well-defined location (because X-rays are minimally scattered) and low background. A spectrochemical indicator film placed over the scintillator layer, e.g., a p

SUBMITTER: Rajamanthrilage AC 

PROVIDER: S-EPMC11267601 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature