Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer.

ABSTRACT:

Background

Breast cancer manifests as a heterogeneous pathology marked by complex metabolic reprogramming essential to satisfy its energy demands. Oncogenic signals boost the metabolism, modifying fatty acid synthesis and glucose use from the onset to progression and therapy resistant-forms. However, the exact contribution of metabolic dependencies during tumor evolution remains unclear.

Methods

In this study, we elucidate the connection between FASN and LDHA, pivotal metabolic genes, and their correlation with tumor grade and therapy response using datasets from public repositories. Subsequently, we evaluated the metabolic and proliferative functions upon FASN and LDHA inhibition in breast cancer models. Lastly, we integrated metabolomic and lipidomic analysis to define the

SUBMITTER: Papulino C 

PROVIDER: S-EPMC11267768 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature