Exploring the therapeutic potential of garlic in alcoholic liver disease: a network pharmacology and experimental validation study.

ABSTRACT:

Objective

Employing network pharmacology and molecular docking, the study predicts the active compounds in garlic and elucidates their mechanism in inhibiting the development of alcoholic liver disease (ALD). ALD is a global chronic liver disease with potential for hepatocellular carcinoma progression.

Methods

The main active ingredients and targets of garlic were identified through screening the TCMSP, TCM-ID, and ETCM databases. ALD disease targets were sourced from DisGeNET, GeneCards, and DiGSeE databases, and intervention targets for garlic were determined through intersections. Protein interaction networks were constructed using the STRING platform, and GO and KEGG pathway enrichment analyses were performed with R software. The garlic component-disease-target network w

SUBMITTER: Gao S 

PROVIDER: S-EPMC11267778 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature