Proteomic profile and predictive markers of outcome in patients with subarachnoid hemorrhage.

ABSTRACT:

Background

The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) following subarachnoid hemorrhage (SAH) remain incompletely understood. Consequently, treatment strategies tailored towards the individual patient remain limited. This study aimed to identify proteomic cerebrospinal fluid (CSF) biomarkers capable of predicting shunt dependency and functional outcome in patients with SAH in order to improve informed clinical decision making.

Methods

Ventricular CSF samples were collected twice from 23 patients with SAH who required external ventricular drain (EVD) insertion (12 patients with successful EVD weaning, 11 patients in need of permanent CSF shunting due to development of PHH). The paired CSF samples were collected acutely after ictus a

SUBMITTER: Lolansen SD 

PROVIDER: S-EPMC11267790 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature