Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response.

ABSTRACT:

Background

Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) generally has a poor prognosis for patients with limited treatment options. While incorporating immune checkpoint inhibitors (ICIs) has now become the standard of care, the efficacy is variable, with only a subset of patients responding. The complexity of the tumor microenvironment (TME) and the role of tertiary lymphoid structures (TLS) have emerged as critical determinants for immunotherapeutic response.

Methods

In this study, we analyzed two independently collected R/M HNSCC patient tissue cohorts to better understand the role of TLS in response to ICIs. Utilizing a multi-omics approach, we first performed targeted proteomic profiling using the Nanostring GeoMx Digital Spatial Profiler to qu

SUBMITTER: Sadeghirad H 

PROVIDER: S-EPMC11267849 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature