The catabolism of ethylene glycol by Rhodococcus jostii RHA1 and its dependence on mycofactocin.

ABSTRACT: Ethylene glycol (EG) is a widely used industrial chemical with manifold applications and also generated in the degradation of plastics such as polyethylene terephthalate. Rhodococcus jostii RHA1 (RHA1), a potential biocatalytic chassis, grows on EG. Transcriptomic analyses revealed four clusters of genes potentially involved in EG catabolism: the mad locus, predicted to encode mycofactocin-dependent alcohol degradation, including the catabolism of EG to glycolate; two GCL clusters, predicted to encode glycolate and glyoxylate catabolism; and the mft genes, predicted to specify mycofactocin biosynthesis. Bioinformatic analyses further revealed that the mad and mft genes are widely distributed in mycolic acid-producing bacteria such as

SUBMITTER: Roccor R 

PROVIDER: S-EPMC11267921 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature