Absence of farnesol salvage in Candida albicans and probably in other fungi.

ABSTRACT: Farnesol salvage, a two-step pathway converting farnesol to farnesyl pyrophosphate (FPP), occurs in bacteria, plants, and animals. This paper investigates the presence of this pathway in fungi. Through bioinformatics, biochemistry, and physiological analyses, we demonstrate its absence in the yeasts Saccharomyces cerevisiae and Candida albicans, suggesting a likely absence across fungi. We screened 1,053 fungal genomes, including 34 from C. albicans, for potential homologs to four genes (Arabidopsis thaliana AtFOLK, AtVTE5, AtVTE6, and Plasmodium falciparum PfPOLK) known to accomplish farnesol/prenol salvage in other organisms. Additionally, we showed that ³H-farnesol was not converted to FPP or any other phosphorylated prenol, an

SUBMITTER: Voshall A 

PROVIDER: S-EPMC11267938 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature