Lifestyle and genetic risk of chronic liver disease in metabolically healthy and unhealthy individuals from the general population.

ABSTRACT:

Background & aims

It is unclear to what extent lifestyle and genetic factors affect the incidence of chronic liver disease (CLD) in the general population and if lifestyle affects CLD independently of underlying cardiometabolic perturbations and genetic predisposition.

Methods

We examined 27,991 men and women aged 44-73 years from the Malmö Diet and Cancer Study recruited between 1991-1996 and followed until the end of 2020 using registry linkage (median follow-up time 25.1 years; 382 incident first-time CLD events). Associations between cardiometabolic factors, polygenic risk scores (PRSs), and lifestyle factors in relation to CLD were examined using multivariable Cox proportional hazards regression models.

Results

The incidence of CLD increased with number of cardio

SUBMITTER: Drake I 

PROVIDER: S-EPMC11268350 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature