Risk Factors for Ovarian Cancer by BRCA Status: A Collaborative Case-Only Analysis.

ABSTRACT:

Background

Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cancer, but the importance of behavioral factors is less clear. We used a case-only design to compare the magnitude of associations with established reproductive, hormonal, and lifestyle risk factors between BRCA mutation carriers and noncarriers.

Methods

We pooled data from five studies from the Ovarian Cancer Association Consortium including 637 BRCA carriers and 4,289 noncarriers. Covariate-adjusted generalized linear mixed models were used to estimate interaction risk ratios (IRR) and 95% confidence intervals (CI), with BRCA (carrier vs. noncarrier) as the response variable.

Results

IRRs were above 1.0 for known protective factors including e

SUBMITTER: Gersekowski K 

PROVIDER: S-EPMC11268497 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature