Microbiota composition effect on immunotherapy outcomes in colorectal cancer patients: A systematic review.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have emerged as an effective treatment for colorectal cancer (CRC). Studies indicate that the composition of gut microbiota could potentially serve as a biomarker for predicting the clinical effectiveness of immune checkpoint inhibitors.

Methods

Following PRISMA guidelines, the review was conducted after registering the protocol with PROSPERO. A comprehensive literature search was carried out across five databases: PubMed, Scopus, Web of Science, Embase, and Cochrane Library. Assessment tools from the National Institutes of Health (NIH) were used to gauge the quality of the studies.

Results

A total of 5,132 papers were identified, and three studies and one conference abstract published between 2017-2022 met the inclusion

SUBMITTER: Ajab SM 

PROVIDER: S-EPMC11268651 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature