A Conformationally Restricted Gold(III) Complex Elicits Antiproliferative Activity in Cancer Cells.

ABSTRACT: Diamine ligands are effective structural scaffolds for tuning the reactivity of transition-metal complexes for catalytic, materials, and phosphorescent applications and have been leveraged for biological use. In this work, we report the synthesis and characterization of a novel class of cyclometalated [C^N] Au(III) complexes bearing secondary diamines including a norbornane backbone, (2R,3S)-N²,N³-dibenzylbicyclo[2.2.1]heptane-2,3-diamine, or a cyclohexane backbone, (1R,2R)-N¹,N²-dibenzylcyclohexane-1,2-diamine. X-ray crystallography confirms the square-planar geometry and chirality at nitrogen. The electronic character of the conformationally restricted norbornane backbone influences the el

SUBMITTER: Gukathasan S 

PROVIDER: S-EPMC11268950 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature