The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose.

ABSTRACT:

Objective

The objective of this study was to identify the transcriptional landscape of insulin resistance (IR) in subcutaneous adipose tissue (SAT) in humans across the spectrum of obesity.

Methods

We used SAT RNA sequencing in 220 individuals with metabolic phenotyping.

Results

We identified a 35-gene signature with high predictive accuracy for homeostatic model of IR that was expressed across a variety of non-immune cell populations. We observed primarily "protective" IR associations for adipocyte transcripts and "deleterious" associations for macrophage transcripts, as well as a high concordance between SAT and visceral adipose tissue (VAT). Multiple SAT genes exhibited dynamic expression 5 years after weight loss surgery and with insulin stimulation. Using availab

SUBMITTER: Mashayekhi M 

PROVIDER: S-EPMC11269023 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature