Association between gut microbiota and adrenal disease: a two-sample Mendelian randomized study.

ABSTRACT:

Background

Some observational studies and clinical experiments suggest a close association between gut microbiota and metabolic diseases. However, the causal effects of gut microbiota on adrenal diseases, including Adrenocortical insufficiency, Cushing syndrome, and Hyperaldosteronism, remain unclear.

Methods

This study conducted a two-sample Mendelian randomization analysis using summary statistics data of gut microbiota from a large-scale genome-wide association study conducted by the MiBioGen Consortium. Summary statistics data for the three adrenal diseases were obtained from the FinnGen study. The study employed Inverse variance weighting, MR-Egger, and MR-PRESSO methods to assess the causal relationship between gut microbiota and these three adrenal diseases. Additiona

SUBMITTER: Zhang YY 

PROVIDER: S-EPMC11269257 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature