Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar Ataxia.

ABSTRACT:

Background

Little is known about the progression of health-related quality of life (HRQoL) and predicting factors in spinocerebellar ataxia (SCA). Such knowledge is crucial to identify modifiable factors promoting everyday life with SCA and attenuating HRQoL decline.

Objectives

This study is to assess HRQoL progression and identify factors affecting SCA patients' HRQoL.

Methods

Longitudinal data (three-year follow-up) of 310 SCA patients of the European SCA3/Machado-Joseph-Disease Initiative (ESMI) (2016-2022) and 525 SCA patients (SCA1, SCA2, SCA3 or SCA6) of the EUROSCA natural history study cohort (2006-2015) were assessed. Both large cohort studies share standardized assessments of clinical measures, SARA, INAS, PHQ-9, and HRQoL (EQ-5D-3L). The association between

SUBMITTER: Weber N 

PROVIDER: S-EPMC11269494 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature