Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos.

ABSTRACT:

Background

The two-pore domain potassium (K2P) channels are a major type of potassium channels that maintain the cell membrane potential by conducting passive potassium leak currents independent of voltage change. They play prominent roles in multiple physiological processes, including neuromodulation, perception of pain, breathing and mood control, and response to volatile anesthetics. Mutations in K2P channels have been linked to many human diseases, such as neuronal and cardiovascular disorders and cancers. Significant progress has been made to understand their protein structures, physiological functions, and pharmacological modifiers. However, their expression and function during embryonic development remain largely unknown.

Results

We employed the zebrafish model and id

SUBMITTER: Park SJ 

PROVIDER: S-EPMC11269526 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature