Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy.

ABSTRACT: About 20% of patients with diabetes suffer from chronic pain with neuropathic characteristics. We investigated the multivariate associations between 92 neurology-related proteins measured in serum from 190 patients with painful and painless diabetic neuropathy. Participants were recruited from the Pain in Neuropathy Study, an observational cross-sectional multicentre study in which participants underwent deep phenotyping. In the exploration cohort, two groups were defined by hierarchical cluster analyses of protein data. The proportion of painless vs painful neuropathy did not differ between the two groups, but one group had a significantly higher grade of neuropathy as measured by the Toronto Clinical Scoring System (TCSS). This finding was replicated in the replication cohort. Analyzing

SUBMITTER: Backryd E 

PROVIDER: S-EPMC11269577 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature