Mitochondrial transfer between BMSCs and Muller promotes mitochondrial fusion and suppresses gliosis in degenerative retina.

ABSTRACT: Mitochondrial dysfunction and Müller cells gliosis are significant pathological characteristics of retinal degeneration (RD) and causing blinding. Stem cell therapy is a promising treatment for RD, the recently accepted therapeutic mechanism is cell fusion induced materials transfer. However, whether materials including mitochondrial transfer between grafted stem cells and recipient's cells contribute to suppressing gliosis and mechanism are unclear. In present study, we demonstrated that bone marrow mesenchymal stem cells (BMSCs) transferred mitochondria to Müller cells by cell fusion and tunneling nanotubes. BMSCs-derived mitochondria (BMSCs-mito) were integrated into mitochondrial network of Müller cells, improving mitochondrial function, reducing oxidative stress and gliosis, which pro

SUBMITTER: Huang X 

PROVIDER: S-EPMC11269791 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature