Association between Human Blood Proteome and the Risk of Myocardial Infarction.

ABSTRACT:

Background

The objective of this study is to estimate the causal relationship between plasma proteins and myocardial infarction (MI) through Mendelian randomization (MR), predict potential target-mediated side effects associated with protein interventions, and ensure a comprehensive assessment of clinical safety.

Methods

From 3 proteome genome-wide association studies (GWASs) involving 9775 European participants, 331 unique blood proteins were screened and chosed. The summary data related to MI were derived from a GWAS meta-analysis, incorporating approximately 61,000 cases and 577,000 controls. The assessment of associations between blood proteins and MI was conducted through MR analyses. A phenome-wide MR (Phe-MR) analysis was subsequently employed to determine the potenti

SUBMITTER: Wang L 

PROVIDER: S-EPMC11270110 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature