Futility of Up-Front Resection for Anatomically Resectable Pancreatic Cancer.

ABSTRACT:

Importance

There are currently no clinically relevant criteria to predict a futile up-front pancreatectomy in patients with anatomically resectable pancreatic ductal adenocarcinoma.

Objectives

To develop a futility risk model using a multi-institutional database and provide unified criteria associated with a futility likelihood below a safety threshold of 20%.

Design, setting, and participants

This retrospective study took place from January 2010 through December 2021 at 5 high- or very high-volume centers in Italy. Data were analyzed during April 2024. Participants included consecutive patients undergoing up-front pancreatectomy at the participating institutions.

Exposure

Standard management, per existing guidelines.

Main outcomes and measures

The main

SUBMITTER: Crippa S 

PROVIDER: S-EPMC11270270 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature