Normothermic liver perfusion derived extracellular vesicles have concentration-dependent immunoregulatory properties.

ABSTRACT: Extracellular vesicles (EVs) are major contributors to immunological responses following solid organ transplantation. Donor derived EVs are best known for their role in transplant rejection through transferring donor major histocompatibility complex proteins to recipient antigen presenting cells, a phenomenon known as ‛cross-decoration'. In contrast, donor liver-derived EVs are associated with organ tolerance in small animal models. Therefore, the cellular source of EVs and their cargo could influence their downstream immunological effects. To investigate the immunological effects of EVs released by the liver in a physiological and transplant-relevant model, we isolated EVs being produced during normothermic ex vivo liver perfusion (NEVLP), a novel method of liver storage prior to transpla

SUBMITTER: Jennings H 

PROVIDER: S-EPMC11270586 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature