A riboswitch-controlled TerC family transporter Alx tunes intracellular manganese concentration in <i>Escherichia coli</i> at alkaline pH.

ABSTRACT: Cells use transition metal ions as structural components of biomolecules and cofactors in enzymatic reactions, making transition metal ions integral cellular components. Organisms optimize metal ion concentration to meet cellular needs by regulating the expression of proteins that import and export that metal ion, often in a metal ion concentration-dependent manner. One such regulation mechanism is via riboswitches, which are 5'-untranslated regions of an mRNA that undergo conformational changes to promote or inhibit the expression of the downstream gene, commonly in response to a ligand. The yybP-ykoY family of bacterial riboswitches shares a conserved aptamer domain that binds manganese ions (Mn²⁺). In Escherichia coli, the yybP-ykoY riboswitch precedes an

SUBMITTER: Sharma R 

PROVIDER: S-EPMC11270866 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature