Clostridioides difficile superoxide reductase mitigates oxygen sensitivity.

ABSTRACT: Clostridioides difficile causes a serious diarrheal disease and is a common healthcare-associated bacterial pathogen. Although it has a major impact on human health, the mechanistic details of C. difficile intestinal colonization remain undefined. C. difficile is highly sensitive to oxygen and requires anaerobic conditions for in vitro growth. However, the mammalian gut is not devoid of oxygen, and C. difficile tolerates moderate oxidative stress in vivo. The C. difficile genome encodes several antioxidant proteins, including a predicted superoxide reductase (SOR) that is upregulated upon exposure to antimicrobial peptides. The goal of this study was to establish SOR enzymatic activity and assess its role in protecting C. difficile ag

SUBMITTER: Kochanowsky R 

PROVIDER: S-EPMC11270899 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature